Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis

@inproceedings{Holtman2015InductionOA,
  title={Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis},
  author={Inge R Holtman and Divya D. A. Raj and Jeremy A. Miller and Wandert Schaafsma and Zhuoran Yin and Nieske Brouwer and Paul D Wes and Thomas Moeller and Marie Orre and Willem Kamphuis and Elly M. Hol and Erik W Boddeke and Bart J. L. Eggen},
  booktitle={Acta neuropathologica communications},
  year={2015}
}
INTRODUCTION Microglia are tissue macrophages of the central nervous system that monitor brain homeostasis and react upon neuronal damage and stress. Aging and neurodegeneration induce a hypersensitive, pro-inflammatory phenotype, referred to as primed microglia. To determine the gene expression signature of priming, the transcriptomes of microglia in aging, Alzheimer's disease (AD), and amyotrophic lateral sclerosis (ALS) mouse models were compared using Weighted Gene Co-expression Network… CONTINUE READING
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