Induction of a Th17 cell response by Helicobacter pylori Urease subunit B.

@article{Zhang2011InductionOA,
  title={Induction of a Th17 cell response by Helicobacter pylori Urease subunit B.},
  author={Jin-Yu Zhang and Tao Liu and Hong Xiang Guo and Xiao-Fei Liu and Yuan Zhuang and Shu D Yu and Li Chen and Chao Wu and Zhuo Hui Zhao and Bin Tang and Ping Luo and Xu-hu Mao and Gang Guo and Yun Shi and Quan-ming Zou},
  journal={Immunobiology},
  year={2011},
  volume={216 7},
  pages={803-10}
}
Th17 cells represent a novel subset of CD4(+) T cells, which is associated with Helicobacter pylori infection. In the present study, we investigated the potential role of Urease subunit B (UreB) in the induction of Th17 cell response. Co-cultured splenic lymphocytes from H. pylori-infected mice with the recombinant UreB (rUreB) elevated IL-17 secretion and caused an increase in the number of Th17 cells. The expression of IL-6 and IL-23 p19 was significantly increased in rUreB-stimulated… CONTINUE READING