Induction of a Ca(2+)-activated K+ channel in human erythrocytes by mechanical stress.

@article{Johnson1992InductionOA,
  title={Induction of a Ca(2+)-activated K+ channel in human erythrocytes by mechanical stress.},
  author={Robert Matthews Johnson and K Tang},
  journal={Biochimica et biophysica acta},
  year={1992},
  volume={1107 2},
  pages={
          314-8
        }
}
Mechanical deformation of normal ATP-replete human erythrocytes increased their permeability to Ca2+ sufficiently to turn on the Ca(2+)-activated K+ channel (the Gardos channel). When Ca2+ is absent, mechanical deformation of normal erythrocytes induces an equivalent increase the permeability of both Na+ and K+, In the presence of 0.1 to 1 mM Ca2+, a further increase in the K+ efflux rate was seen. There was no increase in Na+ flux above that induced by deformation itself. The involvement of… CONTINUE READING
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