Induction of VEGF gene expression by retinoic acid through Sp1-binding sites in retinoblastoma Y79 cells.

@article{Akiyama2002InductionOV,
  title={Induction of VEGF gene expression by retinoic acid through Sp1-binding sites in retinoblastoma Y79 cells.},
  author={Hideo Akiyama and Toru Tanaka and Toshitaka Maeno and Hiroyoshi Kanai and Yasutaka Kimura and Shoji Kishi and Masahiko Kurabayashi},
  journal={Investigative ophthalmology & visual science},
  year={2002},
  volume={43 5},
  pages={1367-74}
}
PURPOSE Vascular endothelial growth factor (VEGF) is an angiogenic peptide that has been implicated in many retinopathies. Although all trans-retinoic acid (atRA) has long been known as an essential factor in the visual cycle, the role of atRA in the pathogenesis of retinal disease remains elusive. In this study, we investigated the effects of atRA on… CONTINUE READING