Induction of VEGF and its Flt-1 receptor after sciatic nerve crush injury.

@article{Islamov2004InductionOV,
  title={Induction of VEGF and its Flt-1 receptor after sciatic nerve crush injury.},
  author={Rustem Robertovich Islamov and Vishnu Chintalgattu and Elena S. Pak and Laxmansa C. Katwa and Alexander K. Murashov},
  journal={Neuroreport},
  year={2004},
  volume={15 13},
  pages={2117-21}
}
Expression of vascular endothelial growth factor and its receptors Flt-1 and Flk-1 was studied in lumbar spinal cord after sciatic nerve crush injury. Immunohistochemical staining revealed strikingly different distribution of VEGF, Flt-1, and Flk-1 in lumbar motor neurons. VEGF was observed both in the nuclei and perikarya, while Flk-1 had cytoplasmic and Flt-1 perinuclear localization. Real-time RT-PCR showed a significant increase in the expression of VEGF and Flt-1 on the injured side of the… CONTINUE READING
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