Induction of Ucp2 expression in brain phagocytes and neurons following murine toxoplasmosis: An essential role of IFN-γ and an association with negative energy balance

@article{Arsenijevic2007InductionOU,
  title={Induction of Ucp2 expression in brain phagocytes and neurons following murine toxoplasmosis: An essential role of IFN-γ and an association with negative energy balance},
  author={Denis Arsenijevic and S{\'e}bastien Clavel and Daniel Sanch{\'i}s and Julie Plamondon and Denis Richard},
  journal={Journal of Neuroimmunology},
  year={2007},
  volume={186},
  pages={121-132}
}
A model of murine toxoplasmosis was used to study cellular and temporal expression of uncoupling protein-2 (Ucp2) in the brain. In situ hybridization indicated that Ucp2 was located in neurons. Nuclei structures involved in energy balance, in particular the nucleus of the solitary tract (NST), was shown to have a positive association between negative energy balance and Ucp2 levels. Infection-induced Ucp2 expression colocalized mainly with microglial cells, but also with infiltrating macrophages… CONTINUE READING

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