Induction of UO-44 gene expression by tamoxifen in the rat uterus and ovary.

@article{Huynh2001InductionOU,
  title={Induction of UO-44 gene expression by tamoxifen in the rat uterus and ovary.},
  author={Hung Quoc Huynh and Chuan Young Ng and Kim Buay Lim and Choon Kiat Ong and Chye Sun Ong and Evelyn Tran and T T Tuyen Nguyen and T. W. Chan},
  journal={Endocrinology},
  year={2001},
  volume={142 7},
  pages={
          2985-95
        }
}
A complementary DNA, uterine-ovarian-specific gene 44 (UO-44), has been isolated from tamoxifen-induced rat uterine complementary DNA library using differential display techniques. UO-44 transcripts are found to be abundant in the uterus and ovary. UO-44 gene expression in the uterus is strictly regulated by estrogens, tamoxifen, and GH, whereas the pure antiestrogen ICI 182780 is inhibitory. Treatment of ovariectomized rats and hypophysectomized rats with tamoxifen and GH, respectively… CONTINUE READING

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