Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches.

@article{Constant1997InductionOT,
  title={Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches.},
  author={Stephanie Louise Constant and Kim Bottomly},
  journal={Annual review of immunology},
  year={1997},
  volume={15},
  pages={
          297-322
        }
}
T helper lymphocytes can be divided into two distinct subsets of effector cells based on their functional capabilities and the profile of cytokines they produce. The Th1 subset of CD4+ T cells secretes cytokines usually associated with inflammation, such as IFN-gamma and TNF and induces cell-mediated immune responses. The Th2 subset produces cytokines such as IL-4 and IL-5 that help B cells to proliferate and differentiate and is associated with humoral-type immune responses. The selective… CONTINUE READING
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