Induction of TNFalpha in macrophages by vanadate is dependent on activation of transcription factor NF-kappaB and free radical reactions.

Abstract

Vanadium-induced TNFalpha production is believed to play an important role in respiratory disease associated with air pollution and occupational exposure. While vanadium is able to induce TNFalpha in macrophages or airway epithelial cells, the underlying mechanism is not well defined. In the present study, mechanisms of vanadate-induced TNFalpha production… (More)

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@article{Ye1999InductionOT, title={Induction of TNFalpha in macrophages by vanadate is dependent on activation of transcription factor NF-kappaB and free radical reactions.}, author={Jianbo Ye and Ming-Xing Ding and X. Zhang and Yon Rojanasakul and S Nedospasov and Val Vallyathan and Vincent Castranova and Xiuren Shi}, journal={Molecular and cellular biochemistry}, year={1999}, volume={198 1-2}, pages={193-200} }