Induction of TNF-alpha and proinflammatory secretory phospholipase A2 by intravenous administration of CAMPATH-1H in patients with rheumatoid arthritis.

@article{Pruzanski1995InductionOT,
  title={Induction of TNF-alpha and proinflammatory secretory phospholipase A2 by intravenous administration of CAMPATH-1H in patients with rheumatoid arthritis.},
  author={Waldemar Pruzanski and Murray B. Urowitz and Brigitte Grouix and Peter Vadas},
  journal={The Journal of rheumatology},
  year={1995},
  volume={22 10},
  pages={1816-9}
}
OBJECTIVE To test the effect of infusions of CAMPATH-1H on levels of proinflammatory secretory phospholipase A2 (sPLA2) and tumor necrosis factor alpha (TNF-alpha) in patients with rheumatoid arthritis (RA). METHODS Two patients with RA were infused with CAMPATH-1H; extracellular nonpancreatic sPLA2 activity was tested using radiolabelled E. coli membrane phospholipid, and circulating TNF-alpha levels were tested by ultrasensitive immunoassay. RESULTS Circulating TNF-alpha began to rise… CONTINUE READING