Induction of TNF Receptor I-Mediated Apoptosis via Two Sequential Signaling Complexes

@article{Micheau2003InductionOT,
  title={Induction of TNF Receptor I-Mediated Apoptosis via Two Sequential Signaling Complexes},
  author={O. Micheau and J. Tschopp},
  journal={Cell},
  year={2003},
  volume={114},
  pages={181-190}
}
Apoptosis induced by TNF-receptor I (TNFR1) is thought to proceed via recruitment of the adaptor FADD and caspase-8 to the receptor complex. TNFR1 signaling is also known to activate the transcription factor NF-kappa B and promote survival. The mechanism by which this decision between cell death and survival is arbitrated is not clear. We report that TNFR1-induced apoptosis involves two sequential signaling complexes. The initial plasma membrane bound complex (complex I) consists of TNFR1, the… Expand
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