Induction of TLR4-dependent CD8+ T cell immunity by murine β-defensin2 fusion protein vaccines.

@article{Park2011InductionOT,
  title={Induction of TLR4-dependent CD8+ T cell immunity by murine β-defensin2 fusion protein vaccines.},
  author={Hyun Jun Park and Hong Qin and Stephanie C Cha and Ravindra H. Sharma and Yeonseok Chung and Kimberly S. Schluns and Sattva S. Neelapu and Willem W. Overwijk and Patrick Hwu and Larry W. Kwak},
  journal={Vaccine},
  year={2011},
  volume={29 18},
  pages={3476-82}
}
Our laboratory previously described the strategy of fusing chemokine receptor ligands to antigens in order to generate immunogenic DNA vaccines. In the present study, we produced mouse β-2 defensin (mBD2) fusion proteins using both ovalbumin (OVA) and gp100 as model antigens. Superior cross-presentation by dendritic cells (DC) was observed for mBD2 fused… CONTINUE READING