Induction of T-kininogen and tumor necrosis factor-alpha by macrophage migration inhibitory factor in vivo.

@article{Nishihira1999InductionOT,
  title={Induction of T-kininogen and tumor necrosis factor-alpha by macrophage migration inhibitory factor in vivo.},
  author={Jun Nishihira and Yuka Mizue and Wataru Sakamoto},
  journal={Seminars in thrombosis and hemostasis},
  year={1999},
  volume={25 6},
  pages={
          557-62
        }
}
Administration of lipopolysaccharide (LPS) induces inflammation and tissue injuries that occasionally results in disseminated intravascular coagulation (DIC). This process is believed to be mediated by vasoactive molecules such as kinins and leads to endothelial damage and obstruction of the microcirculation. In this study, we evaluated the involvement of T-kininogen and macrophage migration inhibitory factor (MIF) in endotoxin-induced systemic inflammation. T-Kininogen is a protein unique to… CONTINUE READING