Induction of T-cell activation by oxidized low density lipoprotein.

@article{Frostegrd1992InductionOT,
  title={Induction of T-cell activation by oxidized low density lipoprotein.},
  author={J Frosteg{\aa}rd and Rongxue Wu and Richardo Giscombe and Gitte Holm and Ann Kari Lefvert and Jan Nilsson},
  journal={Arteriosclerosis and thrombosis : a journal of vascular biology},
  year={1992},
  volume={12 4},
  pages={461-7}
}
Oxidation and scavenger receptor-mediated uptake of low density lipoprotein (LDL) in intimal macrophages are believed to be key events in the development of atherosclerosis. We report here that oxidized LDL increases DNA synthesis, expression of HLA-DR, and interleukin-2 receptors in T cells. The stimulatory effect of oxidized LDL was not due to a direct effect on T cells but required the presence of monocytes. Oxidized LDL also stimulated the release of interleukin-1 beta from monocytes. The… CONTINUE READING

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Oxidized low density lipoprotein induces differentiation and adhesion of human monocytes and the monocytic cell line U937.

Proceedings of the National Academy of Sciences of the United States of America • 1990
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