Induction of Rb-associated protein (RbAp46) by Wilms' tumor suppressor WT1 mediates growth inhibition.

@article{Guan1998InductionOR,
  title={Induction of Rb-associated protein (RbAp46) by Wilms' tumor suppressor WT1 mediates growth inhibition.},
  author={Li-lian Guan and Michael Rauchman and Zhepeng Wang},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 42},
  pages={27047-50}
}
The Wilms' tumor suppressor gene, wt1, encodes a zinc-finger transcription factor, WT1, that plays an important role in controlling urogenital development. Previously, WT1 has been shown to inhibit cell growth and to repress transcription initiated from the promoters of a number of growth-promoting genes. However, few physiological target genes that are transcriptionally activated by WT1 have been established. Using suppression subtractive hybridization polymerase chain reaction, we isolated a… CONTINUE READING

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