Induction of Rat Organic Anion Transporting Polypeptide 2 by Pregnenolone-16 -carbonitrile Is via Interaction with Pregnane X Receptor

Abstract

The rat organic anion transporting polypeptide 2 (oatp2; Slc21a5) is a liver transporter that mediates the uptake of a variety of structurally diverse compounds, and has a high affinity for cardiac glycosides. Treatment of rats with pregnenolone-16 -carbonitrile (PCN), a ligand for the rodent pregnane X receptor (PXR), significantly enhances the rat oatp2… (More)

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@inproceedings{Guo2002InductionOR, title={Induction of Rat Organic Anion Transporting Polypeptide 2 by Pregnenolone-16 -carbonitrile Is via Interaction with Pregnane X Receptor}, author={Grace L. Guo and Jeff L. Staudinger and Kenichiro Ogura and Curtis D. Klaassen}, year={2002} }