Induction of Ran GTP drives ciliogenesis

  title={Induction of Ran GTP drives ciliogenesis},
  author={Shuling Fan and Eileen L. Whiteman and Toby Hurd and Jeremy C. McIntyre and John F. Dishinger and Chia Jen Liu and Jeffrey R. Martens and Kristen J Verhey and Umadevi S Sajjan and Ben L Margolis},
  booktitle={Molecular biology of the cell},
The small GTPase Ran and the importin proteins regulate nucleocytoplasmic transport. New evidence suggests that Ran GTP and the importins are also involved in conveying proteins into cilia. In this study, we find that Ran GTP accumulation at the basal bodies is coordinated with the initiation of ciliogenesis. The Ran-binding protein 1 (RanBP1), which indirectly accelerates Ran GTP → Ran GDP hydrolysis and promotes the dissociation of the Ran/importin complex, also localizes to basal bodies and… CONTINUE READING
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