Induction of ROS-independent JNK-activation-mediated apoptosis by a novel coumarin-derivative, DMAC, in human colon cancer cells.

@article{Lin2014InductionOR,
  title={Induction of ROS-independent JNK-activation-mediated apoptosis by a novel coumarin-derivative, DMAC, in human colon cancer cells.},
  author={Mei-Hsiang Lin and Chia-Hsiung Cheng and Ku-Chung Chen and Wai-Theng Lee and Yen-Fang Wang and Cai-Qin Xiao and Cheng-Wei Lin},
  journal={Chemico-biological interactions},
  year={2014},
  volume={218},
  pages={
          42-9
        }
}
In this study, we investigated the antitumor activity of a novel coumarin derivative, 5,7-dihydroxy-4-methyl-6-(3-methylbutanoyl)-coumarin (DMAC), on colorectal carcinoma. DMAC treatment resulted in substantial proapoptotic activity against colon cancer HCT116 and LoVo cells. Induction of apoptotic characteristics, including cellular shrinkage, chromatin condensation, and Annexin V detection, was observed following DMAC treatment. Mechanistically, we observed that DMAC elicited induction of… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 12 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 32 REFERENCES

a novel chalcone from Alpinia pricei Hayata with potent apoptotic activity: dent JNK-activation-mediated apoptosis by a novel coumarin-derivative

Y. F. Kuo, Y. Z. Su, +4 authors B. Flavokawain
  • ttp://dx.doi.org/10.1016/j.cbi.2014.04.015 502 503 504 505 506 507 508 509 510 511 512 513 514 Q4 515 516 517 8 M.-H. Lin et al. / Chemico-Biological Interactions xxx (2014) xxx–xxx CBI 7036 No. of Pages 8, Model 5G 8 May 2014 involvement of ROS and GADD153 upstream of mitochondria-dependent a
  • 2010

Similar Papers

Loading similar papers…