Induction of RNA-directed DNA methylation upon decondensation of constitutive heterochromatin.

@article{Schoft2009InductionOR,
  title={Induction of RNA-directed DNA methylation upon decondensation of constitutive heterochromatin.},
  author={Vera Karolina Schoft and Nina Chumak and Magdalena Mosiolek and Lucyna Slusarz and Vukoslav Komnenovic and Lynette Brownfield and David Twell and Tetsuji Kakutani and Hisashi Tamaru},
  journal={EMBO reports},
  year={2009},
  volume={10 9},
  pages={1015-21}
}
Centromeric constitutive heterochromatin is marked by DNA methylation and dimethylated histone H3 Lys 9 (H3K9me2) in Arabidopsis. RNA-directed DNA methylation (RdDM) is a process that uses 24-nucleotide (nt) small interfering RNAs (siRNAs) to induce de novo methylation to its homologous DNA sequences. Despite the presence of centromeric 24-nt siRNAs, mutations in genes required for RdDM do not appreciably influence the methylation of centromeric repeats. The mechanism by which constitutive… CONTINUE READING
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