Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors

@article{Takahashi2006InductionOP,
  title={Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors},
  author={Kazutoshi Takahashi and S. Yamanaka},
  journal={Cell},
  year={2006},
  volume={126},
  pages={663-676}
}
  • Kazutoshi Takahashi, S. Yamanaka
  • Published 2006
  • Medicine, Biology
  • Cell
  • Differentiated cells can be reprogrammed to an embryonic-like state by transfer of nuclear contents into oocytes or by fusion with embryonic stem (ES) cells. [...] Key Result Unexpectedly, Nanog was dispensable. These cells, which we designated iPS (induced pluripotent stem) cells, exhibit the morphology and growth properties of ES cells and express ES cell marker genes. Subcutaneous transplantation of iPS cells into nude mice resulted in tumors containing a variety of tissues from all three germ layers…Expand Abstract

    Paper Mentions

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 53 REFERENCES
    Functional Expression Cloning of Nanog, a Pluripotency Sustaining Factor in Embryonic Stem Cells
    • 3,072
    • PDF
    Embryonic stem cell lines derived from human blastocysts.
    • 13,478
    • PDF
    Establishment in culture of pluripotential cells from mouse embryos
    • 7,605
    Nuclear Reprogramming of Somatic Cells After Fusion with Human Embryonic Stem Cells
    • 899
    • PDF
    Formation of Pluripotent Stem Cells in the Mammalian Embryo Depends on the POU Transcription Factor Oct4
    • 3,172
    • PDF
    Stem cells with multilineage potential derived from porcine skin.
    • 161
    Nuclear reprogramming of somatic cells by in vitro hybridization with ES cells
    • 860
    The Homeoprotein Nanog Is Required for Maintenance of Pluripotency in Mouse Epiblast and ES Cells
    • 3,030
    • PDF
    Nuclei of Embryonic Stem Cells Reprogram Somatic Cells
    • 245