Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors

  title={Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors},
  author={Kazutoshi Takahashi and K. Tanabe and M. Ohnuki and M. Narita and T. Ichisaka and Kiichiro Tomoda and S. Yamanaka},
  • Kazutoshi Takahashi, K. Tanabe, +4 authors S. Yamanaka
  • Published 2007
  • Medicine, Biology
  • Cell
  • Successful reprogramming of differentiated human somatic cells into a pluripotent state would allow creation of patient- and disease-specific stem cells. We previously reported generation of induced pluripotent stem (iPS) cells, capable of germline transmission, from mouse somatic cells by transduction of four defined transcription factors. Here, we demonstrate the generation of iPS cells from adult human dermal fibroblasts with the same four factors: Oct3/4, Sox2, Klf4, and c-Myc. Human iPS… CONTINUE READING

    Paper Mentions

    Induced pluripotent stem cells potentially may be useful in the future as an unlimited source of cells for transplantation. The major goal of the project is to develop human iPS… Expand
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