Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors

@article{Takahashi2007InductionOP,
  title={Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors},
  author={Kazutoshi Takahashi and Koji Tanabe and Mari Ohnuki and Megumi Narita and Tomoko Ichisaka and Kiichiro Tomoda and Shinya Yamanaka},
  journal={Cell},
  year={2007},
  volume={131},
  pages={861-872}
}
Successful reprogramming of differentiated human somatic cells into a pluripotent state would allow creation of patient- and disease-specific stem cells. We previously reported generation of induced pluripotent stem (iPS) cells, capable of germline transmission, from mouse somatic cells by transduction of four defined transcription factors. Here, we demonstrate the generation of iPS cells from adult human dermal fibroblasts with the same four factors: Oct3/4, Sox2, Klf4, and c-Myc. Human iPS… CONTINUE READING

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