Induction of P-glycoprotein expression and function in human intestinal epithelial cells (T84).

@article{Haslam2008InductionOP,
  title={Induction of P-glycoprotein expression and function in human intestinal epithelial cells (T84).},
  author={Iain S Haslam and Kirk Jones and Tanya Coleman and Nicholas L. Simmons},
  journal={Biochemical pharmacology},
  year={2008},
  volume={76 7},
  pages={850-61}
}
Intestinal induction of Pgp is known to limit the oral availability of certain drug compounds and give rise to detrimental drug-drug interactions. We have investigated the induction of P-glycoprotein (Pgp; MDR1) activity in a human intestinal epithelial cell line (T84) following pre-exposure to a panel of drug compounds, reported to be Pgp substrates, inhibitors or inducers. Human MDR1-transfected MDCKII epithelial monolayers were used to assess Pgp substrate interactions and inhibition of… CONTINUE READING

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