Induction of Nrf2 and xCT are involved in the action of the neuroprotective antibiotic ceftriaxone in vitro.

@article{Lewerenz2009InductionON,
  title={Induction of Nrf2 and xCT are involved in the action of the neuroprotective antibiotic ceftriaxone in vitro.},
  author={Jan Lewerenz and Philipp Albrecht and Mai-Ly Tran Tien and Nadine Henke and Saravanan Karumbayaram and Harley Ian Kornblum and Martina Wiedau-Pazos and Dave Schubert and Pamela Maher and Axel Methner},
  journal={Journal of neurochemistry},
  year={2009},
  volume={111 2},
  pages={332-43}
}
In amyotrophic lateral sclerosis, down-regulation of the astrocyte-specific glutamate excitatory amino acid transporter 2 is hypothesized to increase extracellular glutamate, thereby leading to excitotoxic motor neuron death. The antibiotic ceftriaxone was recently reported to induce excitatory amino acid transporter 2 and to prolong the survival of mutant superoxide dismutase 1 transgenic mice. Here we show that ceftriaxone also protects fibroblasts and the hippocampal cell line HT22, which… CONTINUE READING

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