Induction of Neurotrophic Factors GDNF and BDNF Associated with the Mechanism of Neurorescue Action of Rasagiline and Ladostigil

@article{Weinreb2007InductionON,
  title={Induction of Neurotrophic Factors GDNF and BDNF Associated with the Mechanism of Neurorescue Action of Rasagiline and Ladostigil},
  author={Orly Weinreb and Tamar Amit and Orit Bar‐Am and Moussa B. H. Youdim},
  journal={Annals of the New York Academy of Sciences},
  year={2007},
  volume={1122}
}
Parkinson's disease (PD) and Alzheimer's disease (AD) are the most common neurodegenerative disorders, although there is no drug or therapeutic treatment to demonstrate disease‐modifying effects. Previous work has proposed that neurodegeneration is linked to a lack of trophic support in those neurons and brain areas associated with PD and AD. Indeed, previous studies have found that neurotrophic factors (NTFs) support neuronal survival in various cellular and animal models of PD and AD. Thus… 
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88 Citations

Prospects of Neurotrophic Factors for Parkinson's Disease: Comparison of Protein and Gene Therapy.
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The emerging and existing possibilities to use NTFs as neurorestorative agents and the ways to improve their efficacy are discussed, and gene therapy and recombinant protein therapy approaches for restoring the dopamine circuitry in PD are compared.
‘‘70th Birthday Professor Riederer’’ Induction of glial cell line-derived and brain-derived neurotrophic factors by rasagiline and (−)deprenyl: a way to a disease-modifying therapy?
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The induction of GDNF and BDNF by these MAO inhibitors by rasagiline and (−)deprenyl is reviewed and the induction of prosurvival genes is discussed in relation to a possible disease-modifying therapy withMAO inhibitors in neurodegenerative disorders.
Induction of GDNF and GFRα-1 Following AAV1-Rheb(S16H) Administration in the Hippocampus in vivo
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It is suggested that AAV1-Rheb(S16H) transduction of hippocampal neurons, resulting in neurotrophic interactions between neurons and astrocytes, may be useful for neuroprotection in the adult hippocampus.
Phytochemicals That Regulate Neurodegenerative Disease by Targeting Neurotrophins: A Comprehensive Review
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The phytochemicals that mediate the signaling pathways involved in neuroprotection specifically neurotrophin-mediated activation of Trk receptors and members of p75NTR superfamily are reviewed.
Challenges and Promises in the Development of Neurotrophic Factor-Based Therapies for Parkinson’s Disease
TLDR
The current status of the potential relevance of NTFs for treating PD is reviewed, taking into consideration experimental evidence, human observational studies, and data from clinical trials.
Selegiline rescues gait deficits and the loss of dopaminergic neurons in a subacute MPTP mouse model of Parkinson's disease.
TLDR
Correlation analysis revealed that gait measurement and GDNF/BDNF levels positively correlated with the number of dopaminergic neurons, demonstrating that selegiline has neurorescue effects that are possibly associated with the induction of NTFs and anti-apoptotic genes.
Revelation in the neuroprotective functions of rasagiline and selegiline: the induction of distinct genes by different mechanisms
TLDR
The authors review their recent results on the molecular mechanisms by which MAO inhibitors prevent the cell death through the induction of antiapoptotic, prosurvival genes in selegiline and rasagiline.
The expanding universe of neurotrophic factors: therapeutic potential in aging and age-associated disorders.
Multiple molecular, cellular, structural and functional changes occur in the brain during aging. Neural cells may respond to these changes adaptively by employing multiple mechanisms in order to…
Neurotrophic molecules in the treatment of neurodegenerative disease with focus on the retina: status and perspectives
TLDR
This article presents selected examples of neurotrophic factors that are currently being tested in animal models or developed for transfer to the clinic, with a major focus on factors with the potential of becoming applicable in various forms of retinal degeneration.
Repairing the parkinsonian brain with neurotrophic factors
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