Induction of Na(+)-K(+)-ATPase and its subunit mRNAs by serum in a rat liver cell line.

@article{Bhutada1990InductionON,
  title={Induction of Na(+)-K(+)-ATPase and its subunit mRNAs by serum in a rat liver cell line.},
  author={Alok Bhutada and Carlos Manuel Perez and David Chon and Faramarz Ismail-Beigi},
  journal={The American journal of physiology},
  year={1990},
  volume={258 6 Pt 1},
  pages={C1044-50}
}
Addition of serum to confluent Clone 9 cells increased the protein, RNA, and DNA content per plate of cells; the increments became manifest within 3-6 h and were sustained for the 48-h duration of study. After the addition of serum, Na(+)-K(+)-ATPase activity was stimulated 1.25- and 1.45-fold at 6 and 12 h, respectively. In cells preincubated in the absence of serum for 24 h, addition of serum increased the abundances of Na(+)-K(+)-ATPase subunit mRNAs, mRNA alpha 1 and mRNA beta, coordinately… CONTINUE READING