Induction of Murine TNBS Colitis Is Strictly Controlled by a Modified Method Using Continuous Inhalation Anesthesia with Sevoflurane

@article{Terai2013InductionOM,
  title={Induction of Murine TNBS Colitis Is Strictly Controlled by a Modified Method Using Continuous Inhalation Anesthesia with Sevoflurane},
  author={Tomohiro Terai and Satoshi Osawa and Shinya Tani and Shinji Oishi and Yoshifumi Arai and Takanori Yamada and Mitsushige Sugimoto and T Furuta and Shigeru Kanaoka and Hiroaki Miyajima and Ken Sugimoto},
  journal={Digestive Diseases and Sciences},
  year={2013},
  volume={59},
  pages={1415-1427}
}
Trinitrobenzenesulfonic acid (TNBS)-induced colitis is one of the most widely used experimental colitis models. However, there is no standard procedure for inducing colitis by TNBS because it is difficult to achieve a uniform distribution of colitis. We have developed a modified method of murine TNBS-induced colitis that involves inhalation anesthesia with sevoflurane combined with both single and repeated TNBS administrations. To compare the usefulness of our newly developed method for… CONTINUE READING

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TNBS in ethanol was administered to C57BL/6J mice held in an inverted vertical position either under continuous inhalation anesthesia with sevoflurane , in accordance with our newly developed method , or by intraperitoneal injection with 2.5 % avertin , in accordance with the conventional procedure .
TNBS in ethanol was administered to C57BL/6J mice held in an inverted vertical position either under continuous inhalation anesthesia with sevoflurane , in accordance with our newly developed method , or by intraperitoneal injection with 2.5 % avertin , in accordance with the conventional procedure .
TNBS in ethanol was administered to C57BL/6J mice held in an inverted vertical position either under continuous inhalation anesthesia with sevoflurane , in accordance with our newly developed method , or by intraperitoneal injection with 2.5 % avertin , in accordance with the conventional procedure .
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