Induction of Microsomal Prostaglandin E Synthase-1 in Human Gingival Fibroblasts


It is well established that prostaglandin E2 (PGE2) plays an important role in inflammatory diseases including periodontitis. Previously we have reported that the inflammatory mediators interleukin-1β (IL-1β) and tumor necrosis factor α (TNFα ) stimulate PGE2 synthesis by inducing mRNA expression of cyclooxygenase-2 (COX-2) in human gingival fibroblasts. In… (More)
DOI: 10.1023/B:IFLA.0000033024.13748.c1


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