Induction of MafBx and Murf ubiquitin ligase mRNAs in rat skeletal muscle after LPS injection.

@article{Dehoux2003InductionOM,
  title={Induction of MafBx and Murf ubiquitin ligase mRNAs in rat skeletal muscle after LPS injection.},
  author={Mischa{\"e}l J M Dehoux and Ronald P van Beneden and Laura Fern{\'a}ndez-Celem{\'i}n and Pascale L Lause and J Thissen},
  journal={FEBS letters},
  year={2003},
  volume={544 1-3},
  pages={214-7}
}
MafBx and Murf are two new rat E3 ubiquitin ligases induced in muscle atrophy. Our goal was to investigate whether lipopolysaccharide (LPS) injection, a model of muscle catabolism, is associated with increased expression of MafBx and Murf. LPS (750 microg/100 g body weight) induces MafBx and Murf mRNA (respectively, 23-fold and 33-fold after 12 h; P<0.001). A transient induction of tumor necrosis factor-alpha mRNA (21-fold; P<0.001 at 3 h) and a decrease of insulin like growth factor-I mRNA (50… CONTINUE READING

From This Paper

Topics from this paper.
57 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 57 extracted citations

Similar Papers

Loading similar papers…