Induction of Macrophage Function in Human THP-1 Cells Is Associated with Rewiring of MAPK Signaling and Activation of MAP3K7 (TAK1) Protein Kinase

@article{Richter2016InductionOM,
  title={Induction of Macrophage Function in Human THP-1 Cells Is Associated with Rewiring of MAPK Signaling and Activation of MAP3K7 (TAK1) Protein Kinase},
  author={Erik A Richter and Katharina Ventz and Manuela Harms and Joerg Mostertz and Falko Hochgr{\"a}fe},
  journal={Frontiers in cell and developmental biology},
  year={2016},
  volume={4},
  pages={21}
}
Macrophages represent the primary human host response to pathogen infection and link the immediate defense to the adaptive immune system. Mature tissue macrophages convert from circulating monocyte precursor cells by terminal differentiation in a process that is not fully understood. Here, we analyzed the protein kinases of the human monocytic cell line THP-1 before and after induction of macrophage differentiation by using kinomics and phosphoproteomics. When comparing the macrophage-like… CONTINUE READING
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