Induction of MMP‐1, MMP‐3 and TIMP‐1 in normal dermal fibroblasts by chronic venous leg ulcer wound fluid *

  title={Induction of MMP‐1, MMP‐3 and TIMP‐1 in normal dermal fibroblasts by chronic venous leg ulcer wound fluid *},
  author={Karthikeashvaren Subramaniam and C. Pech and M. Stacey and H. J. Wallace},
  journal={International Wound Journal},
  • Karthikeashvaren Subramaniam, C. Pech, +1 author H. J. Wallace
  • Published 2008
  • Medicine
  • International Wound Journal
  • In the wound bed of chronic venous leg ulcers, an imbalance of matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) may cause excessive proteolysis and impair wound granulation. Soluble mediators in the wound environment may be responsible for this imbalance. The in vitro effect of wound fluid from venous leg ulcers on dermal fibroblast production of MMP‐1, MMP‐3 and TIMP‐1 was compared with the effect of acute wound fluid from two different sources: fluid from… CONTINUE READING
    41 Citations

    Topics from this paper.

    Pentoxifylline Accelerates Wound Healing Process by Modulating Gene Expression of MMP-1, MMP-3, and TIMP-1 in Normoglycemic Rats
    • Saeed Babaei, Mohammad Bayat
    • Medicine
    • Journal of investigative surgery : the official journal of the Academy of Surgical Research
    • 2015
    • 10
    Behaviour of the plasma concentration of gelatinases and their tissue inhibitors in subjects with venous leg ulcers.
    • 6
    • PDF
    Pressure therapy upregulates matrix metalloproteinase expression and downregulates collagen expression in hypertrophic scar tissue
    • 17
    Implications of Extracellular Matrix Production by Adipose Tissue-Derived Stem Cells for Development of Wound Healing Therapies
    • 26
    • PDF


    Patterns of matrix metalloproteinase and TIMP expression in chronic ulcers
    • 190
    Analysis of the acute and chronic wound environments: the role of proteases and their inhibitors
    • N. Trengove, M. Stacey, +5 authors G. Schultz
    • Medicine
    • Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
    • 1999
    • 776
    • PDF
    Matrix metalloproteinases, gelatinase and collagenase, in chronic leg ulcers.
    • 232
    Mitogenic activity and cytokine levels in non‐healing and healing chronic leg ulcers
    • 384
    MMP-8 is the predominant collagenase in healing wounds and nonhealing ulcers.
    • 313
    Tissue inhibitor of metalloproteinases-1 is decreased and activated gelatinases are increased in chronic wounds.
    • 248
    CD40 engagement modulates the production of matrix metalloproteinases by gingival fibroblasts
    • 33