Induction of Lymphoma in CDF1 Mice by the Food Mutagen, 2‐Amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine

  title={Induction of Lymphoma in CDF1 Mice by the Food Mutagen, 2‐Amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine},
  author={Hiroyasu Esumi and Hiroko Ohgaki and Emiko Kohzen and Shozo Takayama and Takashi Sugimura},
  booktitle={Japanese journal of cancer research : Gann},
The mutagenic compound, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), originally isolated from cooked beef, was tested for carcinogenicity in CDF1 mice of both sexes. When PhIP was given in the diet at a concentration of 0.04%, high incidences and early appearances of lymphomas were observed in both sexes during the 579-day experiment. 

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