Induction of Lymphocyte Apoptosis by Tumor Cell Secretion of FasL-bearing Microvesicles

@article{Andreola2002InductionOL,
  title={Induction of Lymphocyte Apoptosis by Tumor Cell Secretion of FasL-bearing Microvesicles},
  author={Giovanna Andreola and Licia Rivoltini and C. Zago Castelli and Veronica Huber and Paola Maria Perego and Paola Deho and Paola Squarcina and Paola Accornero and Francesco Lozupone and Luana Lugini and Annarita Stringaro and Agnese Molinari and Giuseppe Arancia and Massimo Gentile and Giorgio Parmiani and Stefano Fais},
  journal={The Journal of Experimental Medicine},
  year={2002},
  volume={195},
  pages={1303 - 1316}
}
The hypothesis that FasL expression by tumor cells may impair the in vivo efficacy of antitumor immune responses, through a mechanism known as 'Fas tumor counterattack,' has been recently questioned, becoming the object of an intense debate based on conflicting results. Here we definitely show that FasL is indeed detectable in the cytoplasm of melanoma cells and its expression is confined to multivesicular bodies that contain melanosomes. In these structures FasL colocalizes with both… CONTINUE READING

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