Induction of LIF-mRNA by TGF-beta 1 in Schwann cells.

  title={Induction of LIF-mRNA by TGF-beta 1 in Schwann cells.},
  author={Ichiro Matsuoka and Akio Nakane and K. Kurihara},
  journal={Brain research},
  volume={776 1-2},
Schwann cell is a cell type that forms myelin sheath and provides trophic supports for neuronal cells by producing neurotrophic factors such as neurotrophins and neurokines in both normal and traumatic situations. It was recently reported that after lesion of sciatic nerve, mRNA for cholinergic differentiation factor (CDF)/leukemia inhibitory factor (LIF) is induced in nonneuronal cells in the nerve. However, the source of LIF-mRNA and the mechanism of LIF-mRNA regulation have remained largely… CONTINUE READING

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