Induction of Japanese encephalitis virus-specific cytotoxic T lymphocytes in humans by poxvirus-based JE vaccine candidates.

@article{Konishi1998InductionOJ,
  title={Induction of Japanese encephalitis virus-specific cytotoxic T lymphocytes in humans by poxvirus-based JE vaccine candidates.},
  author={Eiji Konishi and Ichiro Kurane and Peter W. Mason and Robert E. Shope and Niranjan Kanesa-thasan and J J Smucny and Charles H. Hoke and Francis A. Ennis},
  journal={Vaccine},
  year={1998},
  volume={16 8},
  pages={842-9}
}
Poxvirus-based recombinant Japanese encephalitis (JE) vaccine candidates, NYVAC-JEV and ALVAC-JEV, were examined for their ability to induce JE virus-specific cytotoxic T lymphocytes (CTLs) in a phase I clinical trial. These vaccine candidates encoded the JE virus premembrane (prM), envelope (E) and non-structural 1 (NS1) proteins. The volunteers received subcutaneous inoculations with each of these candidates on days 0 and 28, and blood was drawn 2 days before vaccination and on day 58. Anti-E… CONTINUE READING

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