Induction of JAM-A during differentiation of human THP-1 dendritic cells.

  title={Induction of JAM-A during differentiation of human THP-1 dendritic cells.},
  author={Noriko Ogasawara and Takashi Kojima and Mitsuru Go and Jun Fuchimoto and Ryuta Kamekura and Jun-ichi Koizumi and Tsuyoshi Ohkuni and Tomoyuki Masaki and Masaki Murata and Satoshi Tanaka and Shingo Ichimiya and Tetsuo Himi and Norimasa Sawada},
  journal={Biochemical and biophysical research communications},
  volume={389 3},
Junctional adhesion molecule (JAM)-A is not only localized at tight junctions of endothelial and epithelial cells but is also expressed on circulating leukocytes and dendritic cells (DCs). In the present study, to investigate the regulation of JAM-A in DCs, mature DCs were differentiated from the human monocytic cell THP-1 by treatment with IL-4, GM-CSF, TNF-alpha, and ionomycin, and some cells were pretreated with the PPAR-gamma agonists. In the THP-1 monocytes, mRNAs of tight junction… CONTINUE READING


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