Induction of Interferons (IFNs) and Tumor Necrosis Factor (TNF) in Mice by a Novel Glycolipid Trehalose 2,3,6′‐Trimycolate from Rhodococcus aurantiacus (Gordona aurantiaca)

@article{Fujita1990InductionOI,
  title={Induction of Interferons (IFNs) and Tumor Necrosis Factor (TNF) in Mice by a Novel Glycolipid Trehalose 2,3,6′‐Trimycolate from Rhodococcus aurantiacus (Gordona aurantiaca)},
  author={T. Fujita and N. Sugimoto and F. Yokoi and Y. Ohtsubo and M. Ikutoh and Y. Kato and Y. Natsuhara and S. Oka and I. Yano},
  journal={Microbiology and Immunology},
  year={1990},
  volume={34}
}
  • T. Fujita, N. Sugimoto, +6 authors I. Yano
  • Published 1990
  • Biology, Medicine
  • Microbiology and Immunology
  • The immunomodifying activity of a novel mycoloyl glycolipid, trehalose 2,3,6′‐trimycolate (GaGM), from a unique psychrophilic acid‐fast bacterium, Rhodococcus aurantiacus, was examined. ICR mice were primed intravenously (i.v.) or intraperitoneally (i.p.) with liposomes containing GaGM (300 μg/mouse), and were administered LPS dissolved in saline (25 μg/mouse, i.v.) 2 weeks later. Two hours after injection of LPS, interferons (IFNs) and tumor necrosis factor (TNF) were induced significantly in… CONTINUE READING
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