Induction of Inflammation by West Nile virus Capsid through the Caspase-9 Apoptotic Pathway

@inproceedings{Yang2002InductionOI,
  title={Induction of Inflammation by West Nile virus Capsid through the Caspase-9 Apoptotic Pathway},
  author={Joo-Sung Yang and Mathura P. Ramanathan and Karuppiah Muthumani and Andrew Y. Choo and Sung-Ha Jin and Qian-chun Yu and Daniel S. Hwang and Daniel K. Choo and Mark D. Lee and Kesen Dang and Jung-whan Kim and David B. Weiner},
  booktitle={Emerging infectious diseases},
  year={2002}
}
West Nile virus (WNV) is a member of the Flaviviridae family of vector-borne pathogens. Clinical signs of WNV infection include neurologic symptoms, limb weakness, and encephalitis, which can result in paralysis or death. We report that the WNV-capsid by itself induces rapid nuclear condensation and cell death in tissue culture. Apoptosis is induced through the mitochondrial pathway resulting in caspase-9 activation and downstream caspase-3 activation. Capsid gene delivery into the striatum of… CONTINUE READING