Induction of Immune Tolerance to Foreign Protein via Adeno-Associated Viral Vector Gene Transfer in Mid-Gestation Fetal Sheep

@inproceedings{Davey2017InductionOI,
  title={Induction of Immune Tolerance to Foreign Protein via Adeno-Associated Viral Vector Gene Transfer in Mid-Gestation Fetal Sheep},
  author={Marcus G. Davey and John S. Riley and Abigail Andrews and Alec Tyminski and Maria P. Limberis and Jennifer E. Pogoriler and Emily A. Partridge and Aliza Olive and Holly L. Hedrick and Alan W. Flake and William H. Peranteau},
  booktitle={PloS one},
  year={2017}
}
A major limitation to adeno-associated virus (AAV) gene therapy is the generation of host immune responses to viral vector antigens and the transgene product. The ability to induce immune tolerance to foreign protein has the potential to overcome this host immunity. Acquisition and maintenance of tolerance to viral vector antigens and transgene products may… CONTINUE READING