Induction of IgG2a class switching in B cells by IL-27.

@article{Yoshimoto2004InductionOI,
  title={Induction of IgG2a class switching in B cells by IL-27.},
  author={Takayuki Yoshimoto and Keiko Okada and Noriko Morishima and Sadahiro Kamiya and Toshiyuki Owaki and Masayuki Asakawa and Yoichiro Iwakura and Fumio Fukai and Junichiro Mizuguchi},
  journal={Journal of immunology},
  year={2004},
  volume={173 4},
  pages={2479-85}
}
IL-27 is a novel IL-12 family member that plays a role in the early regulation of Th1 initiation. However, its role in B cells remains unexplored. We here show a role for IL-27 in the induction of T-bet expression and regulation of Ig class switching in B cells. Expression of WSX-1, one subunit of IL-27R, was detected at the mRNA level in primary mouse spleen B cells, and stimulation of these B cells by IL-27 rapidly activated STAT1. IL-27 then induced T-bet expression and IgG2a, but not IgG1… CONTINUE READING

From This Paper

Figures and tables from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 60 extracted citations

Differential effects of IL-27 on human B cell subsets.

Journal of immunology • 2006
View 7 Excerpts
Highly Influenced

IL-27 induces the production of IgG1 by human B cells.

European cytokine network • 2006
View 4 Excerpts
Highly Influenced

IL27: its roles in the induction and inhibition of inflammation.

International journal of clinical and experimental pathology • 2008
View 11 Excerpts
Highly Influenced

The T-box transcription factor T-bet in immunity and autoimmunity.

Cellular & molecular immunology • 2006
View 6 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 52 references

T-bet regulates T-independent IgG2a class switching.

International immunology • 2003
View 5 Excerpts
Highly Influenced

T-bet regulates IgG class switching and pathogenic autoantibody production.

Proceedings of the National Academy of Sciences of the United States of America • 2002
View 6 Excerpts
Highly Influenced

IL-27 and IFN-alpha signal via Stat1 and Stat3 and induce T-Bet and IL-12Rbeta2 in naive T cells.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research • 2003

IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms.

Proceedings of the National Academy of Sciences of the United States of America • 2003
View 1 Excerpt

Similar Papers

Loading similar papers…