Induction of IgG2a class switching in B cells by IL-27.

  title={Induction of IgG2a class switching in B cells by IL-27.},
  author={Takayuki Yoshimoto and Keiko Okada and Noriko Morishima and Sadahiro Kamiya and Toshiyuki Owaki and Masayuki Asakawa and Yoichiro Iwakura and Fumio Fukai and Junichiro Mizuguchi},
  journal={Journal of immunology},
  volume={173 4},
IL-27 is a novel IL-12 family member that plays a role in the early regulation of Th1 initiation. However, its role in B cells remains unexplored. We here show a role for IL-27 in the induction of T-bet expression and regulation of Ig class switching in B cells. Expression of WSX-1, one subunit of IL-27R, was detected at the mRNA level in primary mouse spleen B cells, and stimulation of these B cells by IL-27 rapidly activated STAT1. IL-27 then induced T-bet expression and IgG2a, but not IgG1… CONTINUE READING

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