Induction of IL-6 in co-culture of bronchial epithelial cells and eosinophils is regulated by p38 MAPK and NF-kappaB.

@article{Wang2005InductionOI,
  title={Induction of IL-6 in co-culture of bronchial epithelial cells and eosinophils is regulated by p38 MAPK and NF-kappaB.},
  author={C B Wang and Chun Kwok Wong and W. K. Ip and Mandy Li and Ya Ping Tian and C. K. Lam},
  journal={Allergy},
  year={2005},
  volume={60 11},
  pages={1378-85}
}
BACKGROUND Prominent infiltration of eosinophils into the airway mucosa and release of inflammatory mediators upon their adhesion onto airway epithelial cells are the immunopathogical mechanisms of allergic asthma. OBJECTIVE We investigated the effect of normal and paraformaldyhyde-fixed human eosinophils on BEAS-2B cells, a human bronchial epithelial cell line, for the release of inflammatory cytokine interleukin (IL)-6. METHODS Interleukin-6 in cell culture supernatant, protein amount of… CONTINUE READING