Induction of IL-4 by platelet-activating factor.

  title={Induction of IL-4 by platelet-activating factor.},
  author={Yi Hui Huang and Liselotte Sch{\"a}fer-Elinder and H Owman and J C Lorentzen and Johan R{\"o}nnelid and J Frosteg{\aa}rd},
  journal={Clinical and experimental immunology},
  volume={106 1},
Platelet-activating factor (PAF) is a phospholipid inflammatory mediator which is synthesized by a variety of cells, including monocytes, endothelial cells, mast cells and neutrophils. PAF acts via a recently cloned PAF receptor, present on monocytes and endothelial cells, but not on non-activated lymphocytes. IL-4 is mainly produced by T lymphocytes, and belongs to the Th2 subset of T helper cells. IL-6 is mainly a monocyte/macrophage-derived cytokine with multiple proinflammatory effects. We… CONTINUE READING