Induction of IL-15 messenger RNA and protein in human blood-derived dendritic cells: a role for IL-15 in attraction of T cells.

@article{Jonuleit1997InductionOI,
  title={Induction of IL-15 messenger RNA and protein in human blood-derived dendritic cells: a role for IL-15 in attraction of T cells.},
  author={Helmut Jonuleit and Klaus Wiedemann and Guenter Mueller and Joachim Dr Degwert and Udo Hoppe and Juergen Knop and Alexander H Enk},
  journal={Journal of immunology},
  year={1997},
  volume={158 6},
  pages={
          2610-5
        }
}
IL-15 is a pleiotropic cytokine with IL-2-like functions. As IL-15 was shown to be mitogenic for T cells, we wondered whether human blood-derived dendritic cells (DC), as the primary stimulators of T cell responses, are able to produce IL-15. To test our hypothesis, DC were grown under serum-free conditions from human peripheral blood using granulocyte-macrophage CSF and IL-4. Cultures were assayed for IL-15 mRNA production at various times by semiquantitative reverse transcription-PCR. Low… CONTINUE READING

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