Induction of IL-12 and chemokines by hyaluronan requires adhesion-dependent priming of resident but not elicited macrophages.

@article{HodgeDufour1997InductionOI,
  title={Induction of IL-12 and chemokines by hyaluronan requires adhesion-dependent priming of resident but not elicited macrophages.},
  author={J Hodge-Dufour and Paul W. Noble and Maureen R. Horton and Clare Bao and M Wysoka and Marie D. Burdick and Robert M. Strieter and Giorgio Trinchieri and Ellen Pur{\'e}},
  journal={Journal of immunology},
  year={1997},
  volume={159 5},
  pages={2492-500}
}
Components of the extracellular matrix (ECM) can regulate leukocyte activation and function at inflammatory sites. Low molecular weight fragments of the ECM glycosaminoglycan hyaluronan (LMW-HA) that accumulate in inflammation, but not the ubiquitous high molecular weight form of HA (HMW-HA), have been shown to induce cytokine and/or chemokine production by alveolar and bone-marrow derived macrophages. To determine the cellular requirements for responsiveness to HA, we compared the effects of… CONTINUE READING