Induction of IL-10+CD4+CD25+ T cells by grass pollen immunotherapy.

  title={Induction of IL-10+CD4+CD25+ T cells by grass pollen immunotherapy.},
  author={James N. Francis and Stephen John Till and Stephen R. Durham},
  journal={The Journal of allergy and clinical immunology},
  volume={111 6},
BACKGROUND Immunotherapy involves the modulation of allergen-specific T-cell responses, either T(H)2-to-T(H)1 immune deviation or, in bee venom-treated patients, induction of IL-10 production by CD4+CD25+ T cells. IL-10-producing CD4+CD25+ regulatory T cells have emerged as potential mediators of immune tolerance in numerous murine models of immunopathology. OBJECTIVE The aim of this study was to evaluate the role of IL-10 production and CD4+CD25+ T cells in the response to grass pollen… CONTINUE READING


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