Induction of IFN-alpha in peripheral blood mononuclear cells by HIV-infected monocytes. Restricted antiviral activity of the HIV-induced IFN.

@article{Gendelman1992InductionOI,
  title={Induction of IFN-alpha in peripheral blood mononuclear cells by HIV-infected monocytes. Restricted antiviral activity of the HIV-induced IFN.},
  author={Howard E. Gendelman and L M Baca and C A Kubrak and Paul Genis and S Burrous and Robert Marc Friedman and Debra Jacobs and Monte S. Meltzer},
  journal={Journal of immunology},
  year={1992},
  volume={148 2},
  pages={422-9}
}
PBMC cocultured with HIV-infected monocytes for 12 to 48 h released high levels of IFN activity. IFN titers were directly dependent upon time after virus infection and level of HIV replication in infected cells. IFN induction in PBMC was evident with HIV-infected monocytes and PBMC and with myeloid and lymphoblastoid cell lines with at least three different HIV strains. In HIV-infected cell line pairs in which virus infection occurs in both productive and restricted forms, IFN induction in PBMC… CONTINUE READING

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