Induction of Human β-Cell Proliferation and Engraftment Using a Single G1/S Regulatory Molecule, cdk6

@inproceedings{FiaschiTaesch2010InductionOH,
  title={Induction of Human β-Cell Proliferation and Engraftment Using a Single G1/S Regulatory Molecule, cdk6},
  author={Nathalie M. Fiaschi-Taesch and Fatimah G. Salim and Jeffrey W. Kleinberger and Ronnie Troxell and Irene C{\'o}zar-Castellano and Karen Selk and Edward Cherok and Karen K Takane and Donald K Scott and Andrew Francis Stewart},
  booktitle={Diabetes},
  year={2010}
}
OBJECTIVE Most knowledge on human beta-cell cycle control derives from immunoblots of whole human islets, mixtures of beta-cells and non-beta-cells. We explored the presence, subcellular localization, and function of five early G1/S phase molecules-cyclins D1-3 and cdk 4 and 6-in the adult human beta-cell. RESEARCH DESIGN AND METHODS Immunocytochemistry for the five molecules and their relative abilities to drive human beta-cell replication were examined. Human beta-cell replication, cell… CONTINUE READING

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Human beta - cell replication , cell death , and islet function in vivo were studied in the diabetic NOD - SCID mouse .
Human beta - cell replication , cell death , and islet function in vivo were studied in the diabetic NOD - SCID mouse .
Human beta - cell replication , cell death , and islet function in vivo were studied in the diabetic NOD - SCID mouse .
Human beta - cell replication , cell death , and islet function in vivo were studied in the diabetic NOD - SCID mouse .
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