Induction of HO-1 through p38 MAPK/Nrf2 signaling pathway by ethanol extract of Inula helenium L. reduces inflammation in LPS-activated RAW 264.7 cells and CLP-induced septic mice.

@article{Park2013InductionOH,
  title={Induction of HO-1 through p38 MAPK/Nrf2 signaling pathway by ethanol extract of Inula helenium L. reduces inflammation in LPS-activated RAW 264.7 cells and CLP-induced septic mice.},
  author={Eun Jung Park and Young Min Kim and Sang Won Park and Hye Jung Kim and Jae Heun Lee and Dong-Ung Lee and Ki Churl Chang},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2013},
  volume={55},
  pages={386-95}
}
High mobility group box 1 (HMGB1) plays a crucial mediator in the pathogenesis of many inflammatory diseases. We recently proposed that heme oxygenase-1 (HO-1) negatively regulates HMGB1 in inflammatory conditions. We investigated whether ethanol extract of Inula helenium L. (EIH) activates p38 MAPK/Nrf2/HO-1 pathways in RAW264.7 cells and reduces inflammation in CLP-induced septic mice. EIH induced expression of HO-1 protein in a time- and concentration-dependent manner. EIH significantly… CONTINUE READING
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