Induction of HLA-A2-restricted CTLs to the mucin 1 human breast cancer antigen.

  title={Induction of HLA-A2-restricted CTLs to the mucin 1 human breast cancer antigen.},
  author={Vasso Apostolopoulos and Vaios Karanikas and John S. Haurum and Ian F.C. Mckenzie},
  journal={Journal of immunology},
  volume={159 11},
HLA-A*0201/Kb transgenic mice were immunized with oxidized mannan-mucin 1 (MUC1) as a fusion protein (containing five repeats of the 20-amino-acid MUC1 VNTR (variable number of tandem repeats) that generated highly active CD8+ CTLs to MUC1 peptides. In a direct CTL assay, the MUC1 peptides could be presented specifically by both the transgenic murine HLA-A*0201/Kb and human HLA-A*0201 molecules. The 9-mer MUC1 peptide sequences (APDTRPA and STAPPAHGV) were presented by HLA-A*0201, although they… CONTINUE READING


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