Induction of HITS, a newly identified family with sequence similarity 107 protein (FAM107B), in cancer cells by heat shock stimulation.

@article{Nakajima2010InductionOH,
  title={Induction of HITS, a newly identified family with sequence similarity 107 protein (FAM107B), in cancer cells by heat shock stimulation.},
  author={Hideo Nakajima and Yasuhito Ishigaki and Qi-sheng Xia and Takayuki Ikeda and Yoshino Yoshitake and Hideto Yonekura and Takayuki Nojima and Takuji Tanaka and Hisanori Umehara and Naohisa Tomosugi and Takanobu Takata and Takeo Shimasaki and Naoki Nakaya and Itaru Sato and Kazuyuki Kawakami and Keita Koizumi and Toshinari Minamoto and Yoshiharu Motoo},
  journal={International journal of oncology},
  year={2010},
  volume={37 3},
  pages={583-93}
}
The Family with sequence similarity 107 (FAM107) possesses an N-terminal domain of unknown function (DUF1151) that is highly conserved beyond species. In human, FAM107A termed TU3A/DRR1 has been reported as a candidate tumor suppressor gene which expression is downregulated in several types of cancer, however no studies have investigated the other family protein, FAM107B. In the present study, we designated FAM107B as heat shock-inducible tumor small protein (HITS) and studied its expression… CONTINUE READING
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