Induction of G2/M arrest and apoptosis by sesquiterpene lactones in human melanoma cell lines.

@article{Rozenblat2008InductionOG,
  title={Induction of G2/M arrest and apoptosis by sesquiterpene lactones in human melanoma cell lines.},
  author={Sharon Rozenblat and Shlomo Grossman and Margalit Bergman and Hugo Emilio Gottlieb and Yigal Cohen and Sara Dovrat},
  journal={Biochemical pharmacology},
  year={2008},
  volume={75 2},
  pages={369-82}
}
Malignant melanoma is a highly aggressive tumor which frequently resists chemotherapy, therefore, the search for new agents for its treatment is of great importance. In this study, we purified the sesquiterpene lactones (SLs), Tomentosin and Inuviscolide from Inula viscosa (Compositae) leaves and studied their anti-cancer potency against human melanoma cell lines in order to develop new agents for melanoma treatment. SLs inhibited the proliferation of three human melanoma cell lines: SK-28, 624… CONTINUE READING